Wissenschaftliche Publikationen

(2017)
 
Kataoka, K., Mochizuki, K. (2017). Heterochromatin aggregation during DNA elimination in Tetrahymena is facilitated by a prion-like protein. J Cell Sci. 130(2):480-489 (abstract)
 
Suhren, JH., Noto, T., Kataoka, K., Gao, S., Liu, Y., Mochizuki, K. (2017). Negative Regulators of an RNAi-Heterochromatin Positive Feedback Loop Safeguard Somatic Genome Integrity in Tetrahymena. Cell Rep. 18(10):2494-2507 (abstract)
 
(2016)
 
Hamilton, EP., Kapusta, A., Huvos, PE., Bidwell, SL., Zafar, N., Tang, H., Hadjithomas, M., Krishnakumar, V., Badger, JH., Caler, EV., Russ, C., Zeng, Q., Fan, L., Levin, JZ., Shea, T., Young, SK., Hegarty, R., Daza, R., Gujja, S., Wortman, JR., Birren, BW., Nusbaum, C., Thomas, J., Carey, CM., Pritham, EJ., Feschotte, C., Noto, T., Mochizuki, K., Papazyan, R., Taverna, SD., Dear, PH., Cassidy-Hanley, DM., Xiong, J., Miao, W., Orias, E., Coyne, RS. (2016). Structure of the germline genome of Tetrahymena thermophila and relationship to the massively rearranged somatic genome. Elife. 5 (abstract)
 
Kataoka, K., Noto, T., Mochizuki, K. (2016). Phosphorylation of an HP1-like protein is a prerequisite for heterochromatin body formation in Tetrahymena DNA elimination. Proc Natl Acad Sci U S A. 113(32):9027-32 (abstract)
 
(2015)
 
Hayashi, A., Mochizuki, K. (2015). Targeted Gene Disruption by Ectopic Induction of DNA Elimination in Tetrahymena. Genetics. 201(1):55-64 (abstract)
 
Kataoka, K., Mochizuki, K. (2015). Phosphorylation of an HP1-like Protein Regulates Heterochromatin Body Assembly for DNA Elimination. Dev Cell. 35(6):775-88 (abstract)
 
Noto, T., Kataoka, K., Suhren, JH., Hayashi, A., Woolcock, KJ., Gorovsky, MA., Mochizuki, K. (2015). Small-RNA-Mediated Genome-wide trans-Recognition Network in Tetrahymena DNA Elimination. Mol Cell. 59(2):229-42 (abstract)
 
Woehrer, SL., Aronica, L., Suhren, JH., Busch, CJ., Noto, T., Mochizuki, K. (2015). A Tetrahymena Hsp90 co-chaperone promotes siRNA loading by ATP-dependent and ATP-independent mechanisms. EMBO J. 34(4):559-77 (abstract)
 
(2014)
 
Noto, T., Kurth, HM., Mochizuki, K. (2014). Analysis of Piwi-loaded small RNAs in Tetrahymena. Methods Mol Biol. 1093:209-24 (abstract)
 
Vogt, A., Mochizuki, K. (2014). The taming of the shrew: Regulation of a catalytically active domesticated transposase. Mob Genet Elements. 4:e29383 (abstract)
 
(2013)
 
Chalker, DL., Meyer, E., Mochizuki, K. (2013). Epigenetics of ciliates. Cold Spring Harb Perspect Biol. 5(12):a017764 (abstract)
 
Mochizuki, K., Kurth, HM. (2013). Loading and pre-loading processes generate a distinct siRNA population in Tetrahymena. Biochem Biophys Res Commun. 436(3):497-502 (abstract)
 
Vogt, A., Goldman, AD., Mochizuki, K., Landweber, LF. (2013). Transposon domestication versus mutualism in ciliate genome rearrangements. PLoS Genet. 9(8):e1003659 (abstract)
 
Vogt, A., Mochizuki, K. (2013). A domesticated PiggyBac transposase interacts with heterochromatin and catalyzes reproducible DNA elimination in Tetrahymena. PLoS Genet. 9(12):e1004032 (abstract)
 
(2012)
 
Mochizuki, K. (2012). Developmentally programmed, RNA-directed genome rearrangement in Tetrahymena. Dev Growth Differ. 54(1):108-19 (abstract)
 
Schoeberl, UE., Kurth, HM., Noto, T., Mochizuki, K. (2012). Biased transcription and selective degradation of small RNAs shape the pattern of DNA elimination in Tetrahymena. Genes Dev. 26(15):1729-42 (abstract)
 
(2011)
 
Kataoka, K., Mochizuki, K. (2011). Programmed DNA elimination in Tetrahymena: a small RNA-mediated genome surveillance mechanism. Adv Exp Med Biol. 722:156-73 (abstract)
 
Schoeberl, UE., Mochizuki, K. (2011). Keeping the soma free of transposons: programmed DNA elimination in ciliates. J Biol Chem. 286(43):37045-52 (abstract)
 
(2010)
 
Busch, CJ., Vogt, A., Mochizuki, K. (2010). Establishment of a Cre/loxP recombination system for N-terminal epitope tagging of genes in Tetrahymena. BMC Microbiol. 10:191 (abstract)
 
Cheng, CY., Vogt, A., Mochizuki, K., Yao, MC. (2010). A domesticated piggyBac transposase plays key roles in heterochromatin dynamics and DNA cleavage during programmed DNA deletion in Tetrahymena thermophila. Mol Biol Cell. 21(10):1753-62 (abstract)
 
Kataoka, K., Schoeberl, UE., Mochizuki, K. (2010). Modules for C-terminal epitope tagging of Tetrahymena genes. J Microbiol Methods. 82(3):342-6 (abstract)
 
Lukaszewicz, A., Howard-Till, RA., Novatchkova, M., Mochizuki, K., Loidl, J. (2010). MRE11 and COM1/SAE2 are required for double-strand break repair and efficient chromosome pairing during meiosis of the protist Tetrahymena. Chromosoma. 119(5):505-18 (abstract)
 
Mochizuki, K. (2010). RNA-directed epigenetic regulation of DNA rearrangements. Essays Biochem. 48(1):89-100 (abstract)
 
Mochizuki, K. (2010). DNA rearrangements directed by non-coding RNAs in ciliates. Wiley Interdiscip Rev RNA. 1(3):376-87 (abstract)
 
Noto, T., Kurth, HM., Kataoka, K., Aronica, L., DeSouza, LV., Siu, KW., Pearlman, RE., Gorovsky, MA., Mochizuki, K. (2010). The Tetrahymena argonaute-binding protein Giw1p directs a mature argonaute-siRNA complex to the nucleus. Cell. 140(5):692-703 (abstract)
 
(2009)
 
Bednenko, J., Noto, T., DeSouza, LV., Siu, KW., Pearlman, RE., Mochizuki, K., Gorovsky, MA. (2009). Two GW repeat proteins interact with Tetrahymena thermophila argonaute and promote genome rearrangement. Mol Cell Biol. 29(18):5020-30 (abstract)
 
Kurth, HM., Mochizuki, K. (2009). 2'-O-methylation stabilizes Piwi-associated small RNAs and ensures DNA elimination in Tetrahymena. RNA. 15(4):675-85 (abstract)
 
Kurth, HM., Mochizuki, K. (2009). Non-coding RNA: a bridge between small RNA and DNA. RNA Biol. 6(2):138-40 (abstract)
 
Loidl, J., Mochizuki, K. (2009). Tetrahymena meiotic nuclear reorganization is induced by a checkpoint kinase-dependent response to DNA damage. Mol Biol Cell. 20(9):2428-37 (abstract)
 
(2008)
 
Aronica, L., Bednenko, J., Noto, T., DeSouza, LV., Siu, KW., Loidl, J., Pearlman, RE., Gorovsky, MA., Mochizuki, K. (2008). Study of an RNA helicase implicates small RNA-noncoding RNA interactions in programmed DNA elimination in Tetrahymena. Genes Dev. 22(16):2228-41 (abstract)
 
Mochizuki, K. (2008). High efficiency transformation of Tetrahymena using a codon-optimized neomycin resistance gene. Gene. 425(1-2):79-83 (abstract)
 
Mochizuki, K., Novatchkova, M., Loidl, J. (2008). DNA double-strand breaks, but not crossovers, are required for the reorganization of meiotic nuclei in Tetrahymena. J Cell Sci. 121(Pt 13):2148-58 (abstract)
 
(2006)
 
Mochizuki, K. (2006). [RNA directed DNA elimination in Tetrahymena]. Tanpakushitsu Kakusan Koso. 51(16 Suppl):2624-30 (abstract)
 
(2005)
 
Mochizuki, K., Gorovsky, MA. (2005). A Dicer-like protein in Tetrahymena has distinct functions in genome rearrangement, chromosome segregation, and meiotic prophase. Genes Dev. 19(1):77-89 (abstract)
 
(2004)
 
Liu, Y., Mochizuki, K., Gorovsky, MA. (2004). Histone H3 lysine 9 methylation is required for DNA elimination in developing macronuclei in Tetrahymena. Proc Natl Acad Sci U S A. 101(6):1679-84 (abstract)
 
Mochizuki, K., Gorovsky, MA. (2004). Small RNAs in genome rearrangement in Tetrahymena. Curr Opin Genet Dev. 14(2):181-7 (abstract)
 
Mochizuki, K., Gorovsky, MA. (2004). RNA polymerase II localizes in Tetrahymena thermophila meiotic micronuclei when micronuclear transcription associated with genome rearrangement occurs. Eukaryot Cell. 3(5):1233-40 (abstract)
 
Mochizuki, K., Gorovsky, MA. (2004). Conjugation-specific small RNAs in Tetrahymena have predicted properties of scan (scn) RNAs involved in genome rearrangement. Genes Dev. 18(17):2068-73 (abstract)
 
(2002)
 
Mochizuki, K., Fine, NA., Fujisawa, T., Gorovsky, MA. (2002). Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in tetrahymena. Cell. 110(6):689-99 (abstract)
 

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