Wissenschaftliche Publikationen

Abramczuk, MK., Burkard, TR., Rolland, V., Steinmann, V., Duchek, P., Jiang, Y., Wissel, S., Reichert, H., Knoblich, JA. (2017). The splicing co-factor Barricade/Tat-SF1, is required for cell cycle and lineage progression in Drosophila neural stem cells. Development. (abstract)
Bagley, JA., Reumann, D., Bian, S., Lévi-Strauss, J., Knoblich, JA. (2017). Fused cerebral organoids model interactions between brain regions. Nat Methods. 14(7):743-751 (abstract)
Bredenoord, AL., Clevers, H., Knoblich, JA. (2017). Human tissues in a dish: The research and ethical implications of organoid technology. Science. 355(6322) (abstract)
Falk, S., Bugeon, S., Ninkovic, J., Pilz, GA., Postiglione, MP., Cremer, H., Knoblich, JA., Götz, M. (2017). Time-Specific Effects of Spindle Positioning on Embryonic Progenitor Pool Composition and Adult Neural Stem Cell Seeding. Neuron. 93(4):777-791.e3 (abstract)
Huch, M., Knoblich, JA., Lutolf, MP., Martinez-Arias, A. (2017). The hope and the hype of organoid research. Development. 144(6):938-941 (abstract)
Lancaster, MA., Corsini, NS., Wolfinger, S., Gustafson, EH., Phillips, AW., Burkard, TR., Otani, T., Livesey, FJ., Knoblich, JA. (2017). Guided self-organization and cortical plate formation in human brain organoids. Nat Biotechnol. 35(7):659-666 (abstract)
Li, Y., Muffat, J., Omer, A., Bosch, I., Lancaster, MA., Sur, M., Gehrke, L., Knoblich, JA., Jaenisch, R. (2017). Induction of Expansion and Folding in Human Cerebral Organoids. Cell Stem Cell. 20(3):385-396.e3 (abstract)
Renner, M., Lancaster, MA., Bian, S., Choi, H., Ku, T., Peer, A., Chung, K., Knoblich, JA. (2017). Self-organized developmental patterning and differentiation in cerebral organoids. EMBO J. 36(10):1316-1329 (abstract)
Fededa, JP., Esk, C., Mierzwa, B., Stanyte, R., Yuan, S., Zheng, H., Ebnet, K., Yan, W., Knoblich, JA., Gerlich, DW. (2016). MicroRNA-34/449 controls mitotic spindle orientation during mammalian cortex development. EMBO J. 35(22):2386-2398 (abstract)
Knoblich, JA. (2016). Lab-Built Brains. Sci Am. 316(1):26-31 (abstract)
Landskron, L., Knoblich, JA. (2016). You Are What You Eat: Linking Metabolic Asymmetry and Cell Fate Choice. Dev Cell. 37(3):206-8 (abstract)
Luo, C., Lancaster, MA., Castanon, R., Nery, JR., Knoblich, JA., Ecker, JR. (2016). Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain. Cell Rep. 17(12):3369-3384 (abstract)
Wissel, S., Kieser, A., Yasugi, T., Duchek, P., Roitinger, E., Gokcezade, J., Steinmann, V., Gaul, U., Mechtler, K., Förstemann, K., Knoblich, JA., Neumüller, RA. (2016). A Combination of CRISPR/Cas9 and Standardized RNAi as a Versatile Platform for the Characterization of Gene Function. G3 (Bethesda). 6(8):2467-78 (abstract)
Akbari, OS., Bellen, HJ., Bier, E., Bullock, SL., Burt, A., Church, GM., Cook, KR., Duchek, P., Edwards, OR., Esvelt, KM., Gantz, VM., Golic, KG., Gratz, SJ., Harrison, MM., Hayes, KR., James, AA., Kaufman, TC., Knoblich, J., Malik, HS., Matthews, KA., O'Connor-Giles, KM., Parks, AL., Perrimon, N., Port, F., Russell, S., Ueda, R., Wildonger, J. (2015). BIOSAFETY. Safeguarding gene drive experiments in the laboratory. Science. 349(6251):927-9 (abstract)
Ballard, MS., Zhu, A., Iwai, N., Stensrud, M., Mapps, A., Postiglione, MP., Knoblich, JA., Hinck, L. (2015). Mammary Stem Cell Self-Renewal Is Regulated by Slit2/Robo1 Signaling through SNAI1 and mINSC. Cell Rep. 13(2):290-301 (abstract)
Camp, JG., Badsha, F., Florio, M., Kanton, S., Gerber, T., Wilsch-Bräuninger, M., Lewitus, E., Sykes, A., Hevers, W., Lancaster, M., Knoblich, JA., Lachmann, R., Pääbo, S., Huttner, WB., Treutlein, B. (2015). Human cerebral organoids recapitulate gene expression programs of fetal neocortex development. Proc Natl Acad Sci U S A. 112(51):15672-7 (abstract)
Homem, CC., Repic, M., Knoblich, JA. (2015). Proliferation control in neural stem and progenitor cells. Nat Rev Neurosci. 16(11):647-59 (abstract)
Ayukawa, T., Akiyama, M., Mummery-Widmer, JL., Stoeger, T., Sasaki, J., Knoblich, JA., Senoo, H., Sasaki, T., Yamazaki, M. (2014). Dachsous-dependent asymmetric localization of spiny-legs determines planar cell polarity orientation in Drosophila. Cell Rep. 8(2):610-21 (abstract)
Eroglu, E., Burkard, TR., Jiang, Y., Saini, N., Homem, CC., Reichert, H., Knoblich, JA. (2014). SWI/SNF complex prevents lineage reversion and induces temporal patterning in neural stem cells. Cell. 156(6):1259-73 (abstract)
Hagelkruys, A., Lagger, S., Krahmer, J., Leopoldi, A., Artaker, M., Pusch, O., Zezula, J., Weissmann, S., Xie, Y., Schöfer, C., Schlederer, M., Brosch, G., Matthias, P., Selfridge, J., Lassmann, H., Knoblich, JA., Seiser, C. (2014). A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog. Development. 141(3):604-16 (abstract)
Homem, CC., Steinmann, V., Burkard, TR., Jais, A., Esterbauer, H., Knoblich, JA. (2014). Ecdysone and mediator change energy metabolism to terminate proliferation in Drosophila neural stem cells. Cell. 158(4):874-88 (abstract)
Jüschke, C., Xie, Y., Postiglione, MP., Knoblich, JA. (2014). Analysis and modeling of mitotic spindle orientations in three dimensions. Proc Natl Acad Sci U S A. 111(3):1014-9 (abstract)
Lancaster, MA., Knoblich, JA. (2014). Organogenesis in a dish: modeling development and disease using organoid technologies. Science. 345(6194):1247125 (abstract)
Lancaster, MA., Knoblich, JA. (2014). Generation of cerebral organoids from human pluripotent stem cells. Nat Protoc. 9(10):2329-40 (abstract)
Marchetti, G., Reichardt, I., Knoblich, JA., Besse, F. (2014). The TRIM-NHL protein Brat promotes axon maintenance by repressing src64B expression. J Neurosci. 34(41):13855-64 (abstract)
Mauri, F., Reichardt, I., Mummery-Widmer, JL., Yamazaki, M., Knoblich, JA. (2014). The conserved discs-large binding partner Banderuola regulates asymmetric cell division in Drosophila. Curr Biol. 24(16):1811-25 (abstract)
Williams, SE., Ratliff, LA., Postiglione, MP., Knoblich, JA., Fuchs, E. (2014). Par3-mInsc and Gαi3 cooperate to promote oriented epidermal cell divisions through LGN. Nat Cell Biol. 16(8):758-69 (abstract)
Yasugi, T., Fischer, A., Jiang, Y., Reichert, H., Knoblich, JA. (2014). A regulatory transcriptional loop controls proliferation and differentiation in Drosophila neural stem cells. PLoS One. 9(5):e97034 (abstract)
Bardet, AF., Steinmann, J., Bafna, S., Knoblich, JA., Zeitlinger, J., Stark, A. (2013). Identification of transcription factor binding sites from ChIP-seq data at high resolution. Bioinformatics. 29(21):2705-13 (abstract)
Harzer, H., Berger, C., Conder, R., Schmauss, G., Knoblich, JA. (2013). FACS purification of Drosophila larval neuroblasts for next-generation sequencing. Nat Protoc. 8(6):1088-99 (abstract)
Homem, CC., Reichardt, I., Berger, C., Lendl, T., Knoblich, JA. (2013). Long-term live cell imaging and automated 4D analysis of drosophila neuroblast lineages. PLoS One. 8(11):e79588 (abstract)
Jüschke, C., Dohnal, I., Pichler, P., Harzer, H., Swart, R., Ammerer, G., Mechtler, K., Knoblich, JA. (2013). Transcriptome and proteome quantification of a tumor model provides novel insights into post-transcriptional gene regulation. Genome Biol. 14(11):r133 (abstract)
Lancaster, MA., Renner, M., Martin, CA., Wenzel, D., Bicknell, LS., Hurles, ME., Homfray, T., Penninger, JM., Jackson, AP., Knoblich, JA. (2013). Cerebral organoids model human brain development and microcephaly. Nature. 501(7467):373-9 (abstract)
Reichardt, I., Knoblich, JA. (2013). Cell biology: Notch recycling is numbed. Curr Biol. 23(7):R270-2 (abstract)
Sparmann, A., Xie, Y., Verhoeven, E., Vermeulen, M., Lancini, C., Gargiulo, G., Hulsman, D., Mann, M., Knoblich, JA., van Lohuizen, M. (2013). The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation. EMBO J. 32(11):1598-612 (abstract)
Xie, Y., Jüschke, C., Esk, C., Hirotsune, S., Knoblich, JA. (2013). The phosphatase PP4c controls spindle orientation to maintain proliferative symmetric divisions in the developing neocortex. Neuron. 79(2):254-65 (abstract)
Berger, C., Harzer, H., Burkard, TR., Steinmann, J., van der Horst, S., Laurenson, AS., Novatchkova, M., Reichert, H., Knoblich, JA. (2012). FACS purification and transcriptome analysis of drosophila neural stem cells reveals a role for Klumpfuss in self-renewal. Cell Rep. 2(2):407-18 (abstract)
Goulas, S., Conder, R., Knoblich, JA. (2012). The Par complex and integrins direct asymmetric cell division in adult intestinal stem cells. Cell Stem Cell. 11(4):529-40 (abstract)
Homem, CC., Knoblich, JA. (2012). Drosophila neuroblasts: a model for stem cell biology. Development. 139(23):4297-310 (abstract)
Lancaster, MA., Knoblich, JA. (2012). Spindle orientation in mammalian cerebral cortical development. Curr Opin Neurobiol. 22(5):737-46 (abstract)
Khazaei, MR., Bunk, EC., Hillje, AL., Jahn, HM., Riegler, EM., Knoblich, JA., Young, P., Schwamborn, JC. (2011). The E3-ubiquitin ligase TRIM2 regulates neuronal polarization. J Neurochem. 117(1):29-37 (abstract)
Neumüller, RA., Richter, C., Fischer, A., Novatchkova, M., Neumüller, KG., Knoblich, JA. (2011). Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi. Cell Stem Cell. 8(5):580-93 (abstract)
Postiglione, MP., Jüschke, C., Xie, Y., Haas, GA., Charalambous, C., Knoblich, JA. (2011). Mouse inscuteable induces apical-basal spindle orientation to facilitate intermediate progenitor generation in the developing neocortex. Neuron. 72(2):269-84 (abstract)
Richter, C., Oktaba, K., Steinmann, J., Müller, J., Knoblich, JA. (2011). The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. Nat Cell Biol. 13(9):1029-39 (abstract)
Knoblich, JA. (2010). Asymmetric cell division: recent developments and their implications for tumour biology. Nat Rev Mol Cell Biol. 11(12):849-60 (abstract)
Conder, R., Knoblich, JA. (2009). Fly stem cell research gets infectious. Cell. 137(7):1185-7 (abstract)
Coumailleau, F., Fürthauer, M., Knoblich, JA., González-Gaitán, M. (2009). Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division. Nature. 458(7241):1051-5 (abstract)
Mummery-Widmer, JL., Yamazaki, M., Stoeger, T., Novatchkova, M., Bhalerao, S., Chen, D., Dietzl, G., Dickson, BJ., Knoblich, JA. (2009). Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi. Nature. 458(7241):987-92 (abstract)
Neumüller, RA., Knoblich, JA. (2009). Wicked views on stem cell news. Nat Cell Biol. 11(6):678-9 (abstract)
Neumüller, RA., Knoblich, JA. (2009). Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer. Genes Dev. 23(23):2675-99 (abstract)
Schwamborn, JC., Berezikov, E., Knoblich, JA. (2009). The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors. Cell. 136(5):913-25 (abstract)
Barral, Y., Knoblich, J. (2008). Cell division, growth and death. Curr Opin Cell Biol. 20(6):647-9 (abstract)
Benetka, W., Mehlmer, N., Maurer-Stroh, S., Sammer, M., Koranda, M., Neumüller, R., Betschinger, J., Knoblich, JA., Teige, M., Eisenhaber, F. (2008). Experimental testing of predicted myristoylation targets involved in asymmetric cell division and calcium-dependent signalling. Cell Cycle. 7(23):3709-19 (abstract)
Bowman, SK., Rolland, V., Betschinger, J., Kinsey, KA., Emery, G., Knoblich, JA. (2008). The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila. Dev Cell. 14(4):535-46 (abstract)
Jüschke, C., Knoblich, JA. (2008). Purification of Drosophila protein complexes for mass spectrometry. Methods Mol Biol. 420:347-58 (abstract)
Knoblich, JA. (2008). Mechanisms of asymmetric stem cell division. Cell. 132(4):583-97 (abstract)
Neumüller, RA., Betschinger, J., Fischer, A., Bushati, N., Poernbacher, I., Mechtler, K., Cohen, SM., Knoblich, JA. (2008). Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage. Nature. 454(7201):241-5 (abstract)
Schwamborn, JC., Knoblich, JA. (2008). LIS1 and spindle orientation in neuroepithelial cells. Cell Stem Cell. 2(3):193-4 (abstract)
Speicher, S., Fischer, A., Knoblich, J., Carmena, A. (2008). The PDZ protein Canoe regulates the asymmetric division of Drosophila neuroblasts and muscle progenitors. Curr Biol. 18(11):831-7 (abstract)
Wirtz-Peitz, F., Nishimura, T., Knoblich, JA. (2008). Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization. Cell. 135(1):161-73 (abstract)
Knoblich, J. (2007). On the backroads to cellular asymmetry. Development (Cambridge, England). 134(24):4311-3 (abstract)
Betschinger, J., Mechtler, K., Knoblich, JA. (2006). Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Cell. 124(6):1241-53 (abstract)
Bowman, SK., Neumüller, RA., Novatchkova, M., Du, Q., Knoblich, JA. (2006). The Drosophila NuMA Homolog Mud regulates spindle orientation in asymmetric cell division. Dev Cell. 10(6):731-42 (abstract)
Emery, G., Knoblich, JA. (2006). Endosome dynamics during development. Curr Opin Cell Biol. 18(4):407-15 (abstract)
Gallagher, CM., Knoblich, JA. (2006). The conserved c2 domain protein lethal (2) giant discs regulates protein trafficking in Drosophila. Dev Cell. 11(5):641-53 (abstract)
Hutterer, A., Berdnik, D., Wirtz-Peitz, F., Zigman, M., Schleiffer, A., Knoblich, JA. (2006). Mitotic activation of the kinase Aurora-A requires its binding partner Bora. Dev Cell. 11(2):147-57 (abstract)
Knoblich, JA. (2006). Cell biology. Sara splits the signal. Science. 314(5802):1094-6 (abstract)
Vishnu, S., Hertenstein, A., Betschinger, J., Knoblich, JA., Gert de Couet, H., Fischbach, KF. (2006). The adaptor protein X11Lalpha/Dmint1 interacts with the PDZ-binding domain of the cell recognition protein Rst in Drosophila. Dev Biol. 289(2):296-307 (abstract)
Wirtz-Peitz, F., Knoblich, JA. (2006). Lethal giant larvae take on a life of their own. Trends Cell Biol. 16(5):234-41 (abstract)
Betschinger, J., Eisenhaber, F., Knoblich, JA. (2005). Phosphorylation-induced autoinhibition regulates the cytoskeletal protein Lethal (2) giant larvae. Curr Biol. 15(3):276-82 (abstract)
Bhalerao, S., Berdnik, D., Török, T., Knoblich, JA. (2005). Localization-dependent and -independent roles of numb contribute to cell-fate specification in Drosophila. Curr Biol. 15(17):1583-90 (abstract)
Emery, G., Hutterer, A., Berdnik, D., Mayer, B., Wirtz-Peitz, F., Gaitan, MG., Knoblich, JA. (2005). Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system. Cell. 122(5):763-73 (abstract)
Hampoelz, B., Hoeller, O., Bowman, SK., Dunican, D., Knoblich, JA. (2005). Drosophila Ric-8 is essential for plasma-membrane localization of heterotrimeric G proteins. Nat Cell Biol. 7(11):1099-105 (abstract)
Hutterer, A., Knoblich, JA. (2005). Numb and alpha-Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs. EMBO Rep. 6(9):836-42 (abstract)
Jafar-Nejad, H., Andrews, HK., Acar, M., Bayat, V., Wirtz-Peitz, F., Mehta, SQ., Knoblich, JA., Bellen, HJ. (2005). Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors. Dev Cell. 9(3):351-63 (abstract)
Knoblich, JA. (2005). Pins for spines. Nat Cell Biol. 7(12):1157-8 (abstract)
Knoblich, JA. (2005). Neurobiology: getting axons going. Nature. 436(7051):632-3 (abstract)
Mayer, B., Emery, G., Berdnik, D., Wirtz-Peitz, F., Knoblich, JA. (2005). Quantitative analysis of protein dynamics during asymmetric cell division. Curr Biol. 15(20):1847-54 (abstract)
Zarnescu, DC., Jin, P., Betschinger, J., Nakamoto, M., Wang, Y., Dockendorff, TC., Feng, Y., Jongens, TA., Sisson, JC., Knoblich, JA., Warren, ST., Moses, K. (2005). Fragile X protein functions with lgl and the par complex in flies and mice. Dev Cell. 8(1):43-52 (abstract)
Zigman, M., Cayouette, M., Charalambous, C., Schleiffer, A., Hoeller, O., Dunican, D., McCudden, CR., Firnberg, N., Barres, BA., Siderovski, DP., Knoblich, JA. (2005). Mammalian inscuteable regulates spindle orientation and cell fate in the developing retina. Neuron. 48(4):539-45 (abstract)
Betschinger, J., Knoblich, JA. (2004). Dare to be different: asymmetric cell division in Drosophila, C. elegans and vertebrates. Curr Biol. 14(16):R674-85 (abstract)
Hampoelz, B., Knoblich, JA. (2004). Heterotrimeric G proteins: new tricks for an old dog. Cell. 119(4):453-6 (abstract)
Hutterer, A., Betschinger, J., Petronczki, M., Knoblich, JA. (2004). Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis. Dev Cell. 6(6):845-54 (abstract)
Betschinger, J., Mechtler, K., Knoblich, JA. (2003). The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl. Nature. 422(6929):326-30 (abstract)
Blumer, JB., Bernard, ML., Peterson, YK., Nezu, J., Chung, P., Dunican, DJ., Knoblich, JA., Lanier, SM. (2003). Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction of GPR motifs with Gi alpha. J Biol Chem. 278(26):23217-20 (abstract)
Subramanian, A., Prokop, A., Yamamoto, M., Sugimura, K., Uemura, T., Betschinger, J., Knoblich, JA., Volk, T. (2003). Shortstop recruits EB1/APC1 and promotes microtubule assembly at the muscle-tendon junction. Curr Biol. 13(13):1086-95 (abstract)
Berdnik, D., Knoblich, JA. (2002). Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis. Curr Biol. 12(8):640-7 (abstract)
Berdnik, D., Török, T., González-Gaitán, M., Knoblich, JA. (2002). The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila. Dev Cell. 3(2):221-31 (abstract)
Tekotte, H., Berdnik, D., Török, T., Buszczak, M., Jones, LM., Cooley, L., Knoblich, JA., Davis, I. (2002). Dcas is required for importin-alpha3 nuclear export and mechano-sensory organ cell fate specification in Drosophila. Dev Biol. 244(2):396-406 (abstract)
Bulgheresi, S., Kleiner, E., Knoblich, JA. (2001). Inscuteable-dependent apical localization of the microtubule-binding protein Cornetto suggests a role in asymmetric cell division. J Cell Sci. 114(Pt 20):3655-62 (abstract)
Huynh, JR., Petronczki, M., Knoblich, JA., St Johnston, D. (2001). Bazooka and PAR-6 are required with PAR-1 for the maintenance of oocyte fate in Drosophila. Curr Biol. 11(11):901-6 (abstract)
Knoblich, JA. (2001). The Drosophila nervous system as a model for asymmetric cell division. Symp Soc Exp Biol. (53):75-89 (abstract)
Knoblich, JA. (2001). Asymmetric cell division during animal development. Nat Rev Mol Cell Biol. 2(1):11-20 (abstract)
Petronczki, M., Knoblich, JA. (2001). DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila. Nat Cell Biol. 3(1):43-9 (abstract)
Schaefer, M., Knoblich, JA. (2001). Protein localization during asymmetric cell division. Exp Cell Res. 271(1):66-74 (abstract)
Schaefer, M., Petronczki, M., Dorner, D., Forte, M., Knoblich, JA. (2001). Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system. Cell. 107(2):183-94 (abstract)
Knoblich, JA. (2000). Epithelial polarity: the ins and outs of the fly epidermis. Curr Biol. 10(21):R791-4 (abstract)
Schaefer, M., Shevchenko, A., Shevchenko, A., Knoblich, JA. (2000). A protein complex containing Inscuteable and the Galpha-binding protein Pins orients asymmetric cell divisions in Drosophila. Curr Biol. 10(7):353-62 (abstract)
Knoblich, JA., Jan, LY., Jan, YN. (1999). Deletion analysis of the Drosophila Inscuteable protein reveals domains for cortical localization and asymmetric localization. Curr Biol. 9(3):155-8 (abstract)
Schober, M., Schaefer, M., Knoblich, JA. (1999). Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts. Nature. 402(6761):548-51 (abstract)
Glotzer, M., Knoblich, JA. (1998). Cell multiplication - editorial overview. Current Opinion in Cell Biology . 10:739-41
Jacobs, HW., Knoblich, JA., Lehner, CF. (1998). Drosophila Cyclin B3 is required for female fertility and is dispensable for mitosis like Cyclin B. Genes Dev. 12(23):3741-51 (abstract)
Shen, CP., Knoblich, JA., Chan, YM., Jiang, MM., Jan, LY., Jan, YN. (1998). Miranda as a multidomain adapter linking apically localized Inscuteable and basally localized Staufen and Prospero during asymmetric cell division in Drosophila. Genes Dev. 12(12):1837-46 (abstract)
Knoblich, JA. (1997). Mechanisms of asymmetric cell division during animal development. Curr Opin Cell Biol. 9(6):833-41 (abstract)
Knoblich, JA., Jan, LY., Jan, YN. (1997). Asymmetric segregation of the Drosophila numb protein during mitosis: facts and speculations. Cold Spring Harb Symp Quant Biol. 62:71-7 (abstract)
Knoblich, JA., Jan, LY., Jan, YN. (1997). The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localization. Proc Natl Acad Sci U S A. 94(24):13005-10 (abstract)
Frise, E., Knoblich, JA., Younger-Shepherd, S., Jan, LY., Jan, YN. (1996). The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage. Proc Natl Acad Sci U S A. 93(21):11925-32 (abstract)
Kraut, R., Chia, W., Jan, LY., Jan, YN., Knoblich, JA. (1996). Role of inscuteable in orienting asymmetric cell divisions in Drosophila. Nature. 383(6595):50-5 (abstract)
Knoblich, JA., Jan, LY., Jan, YN. (1995). Asymmetric segregation of Numb and Prospero during cell division. Nature. 377(6550):624-7 (abstract)
Kreutzer, MA., Richards, JP., De Silva-Udawatta, MN., Temenak, JJ., Knoblich, JA., Lehner, CF., Bennett, KL. (1995). Caenorhabditis elegans cyclin A- and B-type genes: a cyclin A multigene family, an ancestral cyclin B3 and differential germline expression. J Cell Sci. 108 ( Pt 6):2415-24 (abstract)
Rhyu, MS., Knoblich, JA. (1995). Spindle orientation and asymmetric cell fate. Cell. 82(4):523-6 (abstract)
Sauer, K., Knoblich, JA., Richardson, H., Lehner, CF. (1995). Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis. Genes Dev. 9(11):1327-39 (abstract)
Knoblich, JA., Sauer, K., Jones, L., Richardson, H., Saint, R., Lehner, CF. (1994). Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation. Cell. 77(1):107-20 (abstract)
Knoblich, JA., Lehner, CF. (1993). Synergistic action of Drosophila cyclins A and B during the G2-M transition. EMBO J. 12(1):65-74 (abstract)
Lehner, CF., Ried, G., Stern, B., Knoblich, JA. (1992). Cyclins and cdc2 kinases in Drosophila: genetic analyses in a higher eukaryote. Ciba Found Symp. 170:97-109; discussion 110-4 (abstract)

The Vienna Biocenter in the third district of Vienna has established itself as the premier location for life sciences in Central Europe and is a world-leading international bio-medical research center.


visit the Website