Wissenschaftliche Publikationen

Ebner, P., Poetsch, I., Deszcz, L., Hoffmann, T., Zuber, J., Ikeda, F. (2018). The IAP family member BRUCE regulates autophagosome-lysosome fusion. Nat Commun. 9(1):599 (abstract)
Fennell, L., Rahighi, S., Ikeda, F. (2018). Linear ubiquitin chain-binding domains. FEBS J. (abstract)
Ebner, P., Versteeg, GA., Ikeda, F. (2017). Ubiquitin enzymes in the regulation of immune responses. Crit Rev Biochem Mol Biol. 52(4):425-460 (abstract)
Rittinger, K., Ikeda, F. (2017). Linear ubiquitin chains: enzymes, mechanisms and biology. Open Biol. 7(4) (abstract)
Asaoka, T., Almagro, J., Ehrhardt, C., Tsai, I., Schleiffer, A., Deszcz, L., Junttila, S., Ringrose, L., Mechtler, K., Kavirayani, A., Gyenesei, A., Hofmann, K., Duchek, P., Rittinger, K., Ikeda, F. (2016). Linear ubiquitination by LUBEL has a role in Drosophila heat stress response. EMBO Rep. 17(11):1624-1640 (abstract)
Nastase, MV., Zeng-Brouwers, J., Frey, H., Hsieh, LT., Poluzzi, C., Beckmann, J., Schroeder, N., Pfeilschifter, J., Lopez-Mosqueda, J., Mersmann, J., Ikeda, F., Iozzo, RV., Dikic, I., Schaefer, L. (2016). An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis. Am J Pathol. 186(5):1206-20 (abstract)
Tortola, L., Nitsch, R., Bertrand, MJ., Kogler, M., Redouane, Y., Kozieradzki, I., Uribesalgo, I., Fennell, LM., Daugaard, M., Klug, H., Wirnsberger, G., Wimmer, R., Perlot, T., Sarao, R., Rao, S., Hanada, T., Takahashi, N., Kernbauer, E., Demiröz, D., Lang, M., Superti-Furga, G., Decker, T., Pichler, A., Ikeda, F., Kroemer, G., Vandenabeele, P., Sorensen, PH., Penninger, JM. (2016). The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate. Cell Rep. 16(12):3414 (abstract)
Tortola, L., Nitsch, R., Bertrand, MJM., Kogler, M., Redouane, Y., Kozieradzki, I., Uribesalgo, I., Fennell, LM., Daugaard, M., Klug, H., Wirnsberger, G., Wimmer, R., Perlot, T., Sarao, R., Rao, S., Hanada, T., Takahashi, N., Kernbauer, E., Demiröz, D., Lang, M., Superti-Furga, G., Decker, T., Pichler, A., Ikeda, F., Kroemer, G., Vandenabeele, P., Sorensen, PH., Penninger, JM. (2016). The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate. Cell Rep. 15(7):1481-1492 (abstract)
Wirnsberger, G., Zwolanek, F., Asaoka, T., Kozieradzki, I., Tortola, L., Wimmer, RA., Kavirayani, A., Fresser, F., Baier, G., Langdon, WY., Ikeda, F., Kuchler, K., Penninger, JM. (2016). Inhibition of CBLB protects from lethal Candida albicans sepsis. Nat Med. 22(8):915-23 (abstract)
Asaoka, T., Ikeda, F. (2015). New Insights into the Role of Ubiquitin Networks in the Regulation of Antiapoptosis Pathways. Int Rev Cell Mol Biol. 318:121-58 (abstract)
Ikeda, F. (2015). Linear ubiquitination signals in adaptive immune responses. Immunol Rev. 266(1):222-36 (abstract)
Kumari, S., Redouane, Y., Lopez-Mosqueda, J., Shiraishi, R., Romanowska, M., Lutzmayer, S., Kuiper, J., Martinez, C., Dikic, I., Pasparakis, M., Ikeda, F. (2014). Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis. Elife. 3 (abstract)
Paolino, M., Choidas, A., Wallner, S., Pranjic, B., Uribesalgo, I., Loeser, S., Jamieson, AM., Langdon, WY., Ikeda, F., Fededa, JP., Cronin, SJ., Nitsch, R., Schultz-Fademrecht, C., Eickhoff, J., Menninger, S., Unger, A., Torka, R., Gruber, T., Hinterleitner, R., Baier, G., Wolf, D., Ullrich, A., Klebl, BM., Penninger, JM. (2014). The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature. 507(7493):508-12 (abstract)
Ikeda, F., Lahav, G. (2013). Signal transduction and signaling networks. Mol Biol Cell. 24(6):676 (abstract)
Ikeda, F. (2012). Fumiyo Ikeda: ubiquitin lines up for action. Interview by Caitlin Sedwick. J Cell Biol. 199(3):405-6 (abstract)
Kensche, T., Tokunaga, F., Ikeda, F., Goto, E., Iwai, K., Dikic, I. (2012). Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB. J Biol Chem. 287(28):23626-34 (abstract)
Ikeda, F., Deribe, YL., Skånland, SS., Stieglitz, B., Grabbe, C., Franz-Wachtel, M., van Wijk, SJ., Goswami, P., Nagy, V., Terzic, J., Tokunaga, F., Androulidaki, A., Nakagawa, T., Pasparakis, M., Iwai, K., Sundberg, JP., Schaefer, L., Rittinger, K., Macek, B., Dikic, I. (2011). SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature. 471(7340):637-41 (abstract)
Ikeda, F., Rahighi, S., Wakatsuki, S., Dikic, I. (2011). Selective binding of linear ubiquitin chains to NEMO in NF-kappaB activation. Adv Exp Med Biol. 691:107-14 (abstract)
Ikeda, F., Crosetto, N., Dikic, I. (2010). What determines the specificity and outcomes of ubiquitin signaling? Cell. 143(5):677-81 (abstract)
Matsubara, T., Ikeda, F., Hata, K., Nakanishi, M., Okada, M., Yasuda, H., Nishimura, R., Yoneda, T. (2010). Cbp recruitment of Csk into lipid rafts is critical to c-Src kinase activity and bone resorption in osteoclasts. J Bone Miner Res. 25(5):1068-76 (abstract)
Rahighi, S., Ikeda, F., Kawasaki, M., Akutsu, M., Suzuki, N., Kato, R., Kensche, T., Uejima, T., Bloor, S., Komander, D., Randow, F., Wakatsuki, S., Dikic, I. (2009). Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation. Cell. 136(6):1098-109 (abstract)
Hata, K., Nishimura, R., Muramatsu, S., Matsuda, A., Matsubara, T., Amano, K., Ikeda, F., Harley, VR., Yoneda, T. (2008). Paraspeckle protein p54nrb links Sox9-mediated transcription with RNA processing during chondrogenesis in mice. J Clin Invest. 118(9):3098-108 (abstract)
Iha, H., Peloponese, JM., Verstrepen, L., Zapart, G., Ikeda, F., Smith, CD., Starost, MF., Yedavalli, V., Heyninck, K., Dikic, I., Beyaert, R., Jeang, KT. (2008). Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation. EMBO J. 27(4):629-41 (abstract)
Ikeda, F., Dikic, I. (2008). Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series. EMBO Rep. 9(6):536-42 (abstract)
Ikeda, F., Matsubara, T., Tsurukai, T., Hata, K., Nishimura, R., Yoneda, T. (2008). JNK/c-Jun signaling mediates an anti-apoptotic effect of RANKL in osteoclasts. J Bone Miner Res. 23(6):907-14 (abstract)
Nishimura, R., Hata, K., Ikeda, F., Ichida, F., Shimoyama, A., Matsubara, T., Wada, M., Amano, K., Yoneda, T. (2008). Signal transduction and transcriptional regulation during mesenchymal cell differentiation. J Bone Miner Metab. 26(3):203-12 (abstract)
Wagner, S., Carpentier, I., Rogov, V., Kreike, M., Ikeda, F., Löhr, F., Wu, CJ., Ashwell, JD., Dötsch, V., Dikic, I., Beyaert, R. (2008). Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins. Oncogene. 27(26):3739-45 (abstract)
Ikeda, F., Hecker, CM., Rozenknop, A., Nordmeier, RD., Rogov, V., Hofmann, K., Akira, S., Dötsch, V., Dikic, I. (2007). Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes. EMBO J. 26(14):3451-62 (abstract)
Shimoyama, A., Wada, M., Ikeda, F., Hata, K., Matsubara, T., Nifuji, A., Noda, M., Amano, K., Yamaguchi, A., Nishimura, R., Yoneda, T. (2007). Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function. Mol Biol Cell. 18(7):2411-8 (abstract)
Terzic, J., Marinovic-Terzic, I., Ikeda, F., Dikic, I. (2007). Ubiquitin signals in the NF-kappaB pathway. Biochem Soc Trans. 35(Pt 5):942-5 (abstract)
Ikeda, F., Dikic, I. (2006). CYLD in ubiquitin signaling and tumor pathogenesis. Cell. 125(4):643-5 (abstract)
Ikeda, F., Nishimura, R., Matsubara, T., Hata, K., Reddy, SV., Yoneda, T. (2006). Activation of NFAT signal in vivo leads to osteopenia associated with increased osteoclastogenesis and bone-resorbing activity. J Immunol. 177(4):2384-90 (abstract)
Matsubara, T., Myoui, A., Ikeda, F., Hata, K., Yoshikawa, H., Nishimura, R., Yoneda, T. (2006). Critical role of cortactin in actin ring formation and osteoclastic bone resorption. J Bone Miner Metab. 24(5):368-72 (abstract)
Hata, K., Nishimura, R., Ueda, M., Ikeda, F., Matsubara, T., Ichida, F., Hisada, K., Nokubi, T., Yamaguchi, A., Yoneda, T. (2005). A CCAAT/enhancer binding protein beta isoform, liver-enriched inhibitory protein, regulates commitment of osteoblasts and adipocytes. Mol Cell Biol. 25(5):1971-9 (abstract)
Hiraga, T., Hata, K., Ikeda, F., Kitagaki, J., Fujimoto-Ouchi, K., Tanaka, Y., Yoneda, T. (2005). Preferential inhibition of bone metastases by 5'-deoxy-5-fluorouridine and capecitabine in the 4T1/luc mouse breast cancer model. Oncol Rep. 14(3):695-9 (abstract)
Ichida, F., Nishimura, R., Hata, K., Matsubara, T., Ikeda, F., Hisada, K., Yatani, H., Cao, X., Komori, T., Yamaguchi, A., Yoneda, T. (2004). Reciprocal roles of MSX2 in regulation of osteoblast and adipocyte differentiation. J Biol Chem. 279(32):34015-22 (abstract)
Ikeda, F., Nishimura, R., Matsubara, T., Tanaka, S., Inoue, J., Reddy, SV., Hata, K., Yamashita, K., Hiraga, T., Watanabe, T., Kukita, T., Yoshioka, K., Rao, A., Yoneda, T. (2004). Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation. J Clin Invest. 114(4):475-84 (abstract)
Hata, K., Nishimura, R., Ikeda, F., Yamashita, K., Matsubara, T., Nokubi, T., Yoneda, T. (2003). Differential roles of Smad1 and p38 kinase in regulation of peroxisome proliferator-activating receptor gamma during bone morphogenetic protein 2-induced adipogenesis. Mol Biol Cell. 14(2):545-55 (abstract)
Hiraga, T., Ueda, A., Tamura, D., Hata, K., Ikeda, F., Williams, PJ., Yoneda, T. (2003). Effects of oral UFT combined with or without zoledronic acid on bone metastasis in the 4T1/luc mouse breast cancer. Int J Cancer. 106(6):973-9 (abstract)
Nishimura, R., Hata, K., Ikeda, F., Matsubara, T., Yamashita, K., Ichida, F., Yoneda, T. (2003). The role of Smads in BMP signaling. Front Biosci. 8:s275-84 (abstract)
Nishimura, R., Hata, K., Harris, SE., Ikeda, F., Yoneda, T. (2002). Core-binding factor alpha 1 (Cbfa1) induces osteoblastic differentiation of C2C12 cells without interactions with Smad1 and Smad5. Bone. 31(2):303-12 (abstract)

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